V Castronovo Selected Research

O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)

1/2000

TNP-470, a potent angiogenesis inhibitor, amplifies human T lymphocyte activation through an induction of nuclear factor-kappaB, nuclear factor-AT, and activation protein-1 transcription factors.

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V Castronovo Research Topics

Disease

17	Neoplasms (Cancer) 01/2017 - 01/2000
6	Prostatic Neoplasms (Prostate Cancer) 11/2006 - 05/2000
5	Breast Neoplasms (Breast Cancer) 01/2017 - 05/2000
4	Neoplasm Metastasis (Metastasis) 09/2010 - 05/2000
3	Carcinoma (Carcinomatosis) 01/2001 - 01/2000
2	Adenocarcinoma 12/2004 - 01/2000
1	Glioblastoma (Glioblastoma Multiforme) 01/2016
1	Colonic Neoplasms (Colon Cancer) 10/2015
1	Megacolon 07/2006
1	Hirschsprung Disease (Hirschsprung's Disease) 07/2006
1	Constipation 07/2006
1	Adenocarcinoma of Lung 08/2003
1	Lung Neoplasms (Lung Cancer) 08/2003
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2003
1	Lymphoma (Lymphomas) 04/2001
1	Pathologic Processes 01/2001
1	Prostatic Intraepithelial Neoplasia 01/2001
1	Multiple Myeloma 12/2000
1	Disease Progression 07/2000

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 09/2010 - 05/2000
5	Histone Deacetylases (Histone Deacetylase)IBA 01/2017 - 07/2004
4	Integrin-Binding SialoproteinIBA 02/2008 - 05/2000
2	Biological ProductsIBA 07/2012 - 09/2010
2	DNA (Deoxyribonucleic Acid)IBA 07/2012 - 01/2000
2	Messenger RNA (mRNA)IBA 08/2003 - 12/2000
2	Laminin ReceptorsIBA 11/2001 - 04/2001
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2001 - 01/2000
2	Prostate-Specific Antigen (Semenogelase)IBA 01/2001 - 07/2000
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Glutamine (L-Glutamine)FDA Link 01/2017
1	Histone Deacetylase InhibitorsIBA 01/2017
1	ErbB Receptors (EGF Receptor)IBA 01/2017
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2016
1	Vitamin D FDA LinkGeneric 10/2015
1	EnzymesIBA 07/2012
1	HeterochromatinIBA 07/2012
1	Biomarkers (Surrogate Marker)IBA 01/2009
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 02/2008
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 02/2008
1	Transcription Factors (Transcription Factor)IBA 02/2008
1	FlavonoidsIBA 11/2006
1	xanthohumolIBA 11/2006
1	8-prenylnaringeninIBA 11/2006
1	isoxanthohumolIBA 11/2006
1	6-prenylnaringeninIBA 11/2006
1	FlavanonesIBA 11/2006
1	ChalconesIBA 11/2006
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 07/2006
1	Eosine Yellowish-(YS) (Eosin)IBA 07/2006
1	AntibodiesIBA 07/2006
1	Actins (F Actin)IBA 07/2006
1	CaspasesIBA 12/2004
1	NF-kappa B (NF-kB)IBA 12/2004
1	AndrogensIBA 12/2004
1	OsteopontinIBA 08/2003
1	Extracellular Matrix ProteinsIBA 08/2003
1	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 07/2003
1	Omega-6 Fatty Acids (Omega 6 Fatty Acids)IBA 04/2003
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2003
1	Glutathione (Reduced Glutathione)IBA 08/2001
1	Laminin (Merosin)IBA 01/2001
1	ParaffinIBA 01/2001
1	Galectins (Galectin)IBA 01/2001
1	Galectin 1 (LGALS1)IBA 01/2001
1	beta-galactosideIBA 01/2001
1	Galectin 3 (LGALS3)IBA 07/2000
1	CytokinesIBA 01/2000
1	fumagillinIBA 01/2000
1	Angiogenesis InhibitorsIBA 01/2000
1	Pharmaceutical PreparationsIBA 01/2000
1	Interferon-gamma (Interferon, gamma)IBA 01/2000
1	laminin 1IBA 01/2000
1	O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA 01/2000

Therapy/Procedure

5	Therapeutics 01/2017 - 01/2009
1	Prostatectomy (Retropubic Prostatectomy) 11/2001